Ipamorelin is a peptide made up of 5 amino acids (making it a pentapeptide) and acts as a growth hormone secretagogue, meaning it stimulates the pituitary gland to release growth hormone. Ipamorelin is considered the first GHRP (Growth Hormone Releasing Peptide) agonist that selectively stimulates growth hormone, binding to cellular receptors and triggering an intracellular response.
Ipamorelin also mimics ghrelin, a hormone produced by the body commonly known as the "hunger hormone," which tells the brain that you are hungry. By mimicking ghrelin, ipamorelin can be used to stimulate appetite, as shown in several studies. It's important to note that ipamorelin is not a ghrelin secretagogue and should not be used as one; it simply imitates ghrelin.
What is Ipamorelin?
Ipamorelin is a short peptide sequence capable of binding to the ghrelin/growth hormone secretagogue receptor. It is one of the most selective growth hormone (GH) secretagogues known, and studies have shown that it has no effect on ACTH, prolactin, follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, or cortisol release. Due to its high specificity, ipamorelin has been of interest in research both as a therapeutic agent and as a model peptide for understanding how receptor selectivity is achieved.
Ipamorelin | Peptide
Freedom Research
To use Ipamorelin, it is typically administered via subcutaneous injections, with a recommended dosage of 200 to 300 mcg, 1-3 times daily. It’s best taken on an empty stomach to enhance effectiveness. The peptide is often used in cycles, typically up to 12-16 weeks, depending on the goals. For optimal results, avoid eating for at least 30-60 minutes before and after injection. Always consult a healthcare provider before starting Ipamorelin to ensure proper dosage and usage.